Wilforlide A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Wilforlide A 是从雷公藤乙醇提取物中分离出来的天然产物。

Wilforlide A, also known as Regelide and Abruslactone A, is an active compound in Tripterygium wilfordii Hook F (TW) which is a traditional Chinese medicine for treatment of autoimmune diseases, is a quality control marker for TW product.

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Wilforlide A (60-300 μg/kg) markedly inhibits mice auricular swelling induced by dimethylbenzene in ICR mice. Wilforlide A exhibits inhibition rates with 50.9% and 12.29% for high dose and low dose Wilforlide A, resepectively. Wilforlide A (30-150 μg/kg) markedly inhibits rat granulation induced by tampon.

Wilforlide A | Regelide | Abruslactone A

Metabolic Enzyme/Protease

Lipase

Others

Inflammation/Immunology

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84104-71-2

454.7

C30H46O3

>98% (HPLC)

In Vitro:?DMSO : 1 mg/mL (2.20 mM)

O[C@@H]1C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)[C@H]6OC(=O)[C@](C)(C6)C[C@H]5C4=CC[C@@H]3[C@]2(CC1)C

(2S,5S,5aR,7aS,7bR,9aR,11S,13aR,13bR,15bS)-11-hydroxy-2,5a,7a,7b,10,10,13a-heptamethyl-1,5,5a,6,7,7a,7b,8,9,9a,10,11,12,13,13a,13b,14,15b-octadecahydro-2,5-methanochryseno[2,1-c]oxepin-3(2H)-one

(-20℃)

With Ice Pack

≥ 2 years